Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight
Link to the paper: https://www.mdpi.com/2073-4425/13/3/473 The paper investigates gene networks to repurpose drugs for treating skeletal muscle atrophy in conditions like aging, diabetes, and spaceflights. It identifies key genes causing muscle atrophy and uses advanced algorithms like graph convolutional networks to predict gene-disease associations and select potential drugs for repurposing. 🟣Contributions of the paper 🔸The […]
In vitro relationships of galactic cosmic radiation and epigenetic clocks in human bronchial epithelial cells
Link to the paper: https://pubmed.ncbi.nlm.nih.gov/35470505/ Ionizing radiation, a known health risk, was studied for its impact on DNA methylation-based markers of biological age in human bronchial epithelial cells. High-LET 56Fe ions were significantly associated with accelerated epigenetic clock epiTOC2, indicating potential utility of epigenetic clocks in monitoring the health effects of galactic cosmic radiation. The […]
Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration
Plants like Arabidopsis thaliana can grow in lunar regolith from Apollo missions, but they face challenges in development and show stress morphologies. Plants grown in lunar soils exhibit gene expression related to ionic stresses, similar to reactions to salt, metal, and reactive oxygen species, indicating the need for further understanding and mitigation for efficient use […]
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight
Related Articles Potential of Diacylglycerol Kinase in Biomedical Research Seizures The study investigates the downregulation of diacylglycerol kinase in a Drosophila mutant during spaceflight, potentially impacting longevity . Using omics data from Drosophila reared in microgravity, the research aims to identify critical targets for promoting longevity in space missions, highlighting the importance of understanding gene […]
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
Civilian spaceflight prompted researchers to study spaceflight effects on human physiology, focusing at the molecular level. Long-read RNA sequencing of astronaut blood showed genetic pathway changes like erythrocyte regulation, stress induction, and immune changes influenced by spaceflight, along with a significant increase in m6A levels post-flight. Contributions of the Paper Revealed key genetic pathways influenced […]
SpaceX Inspiration4 Mission
In September 2021, SpaceX’s Inspiration4 mission marked a historic milestone as four private astronauts embarked on a three-day journey to low Earth orbit. Beyond its groundbreaking achievement in commercial spaceflight, the mission also represented a significant opportunity for scientific exploration, particularly in the field of biomedical research. The crew collected various biospecimen samples before, during, […]
NASA’s Laser Relay System: Advancing Space Communication with Pet Imagery
NASA’s latest technological breakthrough has not only advanced space communication but also brought a touch of home to the International Space Station (ISS). Using NASA’s first two-way, end-to-end laser relay system, pictures and videos of cherished pets have been transmitted through space at a rate of 1.2 gigabits per second—faster than most home internet speeds. […]
NASA-IBM Collaboration Develops INDUS Large Language Models for Advanced Science Research
Innovative collaborations with private, non-federal partners are a cornerstone of the work done by NASA’s Interagency Implementation and Advanced Concepts Team (IMPACT). One such collaboration with International Business Machines (IBM) has yielded INDUS, a groundbreaking suite of large language models (LLMs) designed specifically for the domains of Earth science, biological and physical sciences, heliophysics, planetary […]
The Role of Computational Chemistry in Space Exploration
Space exploration has always pushed the boundaries of human knowledge and technological capability. As we venture further into the cosmos, the challenges we face become increasingly complex, requiring innovative solutions and advanced technologies. One such technology that has become indispensable in modern space exploration is computational chemistry. This discipline, which uses computer simulations to model […]
The Crucial Role of Chemistry in Space Exploration
Space exploration has always fascinated humanity, pushing the boundaries of our scientific understanding and technological capabilities. At the heart of these endeavors lies the often-overlooked field of chemistry. From propelling rockets into space to sustaining life aboard spacecraft, chemistry is an indispensable component of space missions. This article delves into the multifaceted contributions of chemistry […]